KMID : 0360220160570091386
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Journal of the Korean Ophthalmological Society 2016 Volume.57 No. 9 p.1386 ~ p.1391
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Effect of a Preservative-free Dorzolamide/Timolol Fixed Combination on Elevated Intraocular Pressure after Vitrectomy
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Lee Sung-Hoon
Lee Won-Seok Seong Gong-Je Beyun Sek-Ho Kim Sung-Soo Koh Hyung-Jun Lee Sung-Chul Kim Min
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Abstract
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Purpose: To verify the effect of preservative-free Dorzolamide/Timolol fixed combination (PFDTC) on intraocular pressure (IOP) elevation after vitrectomy.
Methods: We retrospectively reviewed medical records of 33 patients who used PFDTC after pars plana vitrectomy. All patients¡¯ visual acuity and IOP was measured and symptoms of conjunctival irritation were investigated through survey and slit lamp examination.
Results: Before vitrectomy, the mean IOP was 13.6 ¡¾ 4.4 mm Hg which was elevated to 31.7 ¡¾ 5.4 mm Hg after vitrectomy (p < 0.001) and applying eyedrop lowered the mean IOP to 17.2 ¡¾ 7.0 mm Hg (p < 0.001). Regardless of tamponade material type, all elevated IOP decreased (p < 0.001) and the IOP of all 33 eyes did not rise to over 30 mm Hg again. No additional surgery for IOP control was needed during two-month follow-up period. Of the 33 patients using PFDTC, patients who felt discomfort were five (15.2%) and no patients showed side effects severe enough to stop use of eyedrop.
Conclusions: PFDTC is an anti-glaucomatic agent which can reduce the IOP by inhibiting aqueous humor production. Without need for additional surgery, the eyedrop can effectively lower elevated post-vitrectomy IOP, with expectation of good patient compliance due to low risk of conjunctival irritation.
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KEYWORD
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Cosopt-S¨Þ, Eyedrops, Intraocular pressure, Preservative-free, Vitrectomy
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